Synthetic Route of 55717-45-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55717-45-8, name is 6-Bromopyridin-3-ol. A new synthetic method of this compound is introduced below.
Example 14a) 5-Benzyloxy-2-bromo-pyridineJTTo a solution of 10.0 g (57.47 mmol) of 2-bromo-5-hydroxypyridine in 400 mL DMF was added 14.75 g (86.21 mmol) of benzyl bromide and 23.82 g (172.4 mmol) of potassium carbonate. The mixture was stirred for 6 h at 600C and overnight at room temperature. The suspension was filtered off and after evaporation of the solvent the residue was chromatogra- phed on silica gel using a dichloromethane/methanol gradient. Yield: 14.82 g (96.7 %).MS (ESIpos): m/z = 264, 266 [M+H]+ 1H-NMR (300MHz, CHLOROFORM-d): delta [ppm]= 5.10 (s, 2H), 7.16 (dd, 1 H), 7.32 – 7.47 (m, 6H), 8.14 (d, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55717-45-8, its application will become more common.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; SCHMITT-WILLICH, Heribert; ROeHN, Ulrike; FRIEBE, Matthias; LEHMANN, Lutz; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNEIDER, Damian; DYRKS, Thomas; THIELE, Andreas; BOeMER, Ulf; MOeNNING, Ursula; HEINRICH, Tobias; WO2010/28776; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem