Related Products of 849067-90-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 849067-90-9 as follows.
3-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde A solution of 1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (Intermediate 3a) (2.4 g, 16.3 mmol, 1.0 eq.) and NIS (3.7 g, 16.3 mmol, 1.0 eq.) in DMF (25 mL) was stirred at rt overnight. The reaction mixture was diluted with water (50 mL) and a saturated solution of Na2SO3 (2 mL). The formed precipitate was collected by filtration, rinsed with water and dried to give 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (Intermediate 3b) as a solid (4.0 g; yield: 91percent; UPLC purity: 100percent).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,849067-90-9, its application will become more common.
Reference:
Patent; Felicitex Therapeutics, Inc.; Selvita S.A.; Dreas, Agnieszka; Fabritius, Charles-Henry; Dzienia, Andrzej; Buda, Anna; Galezowski, Michal; Kachkovskyi, Georgiy; Kulesza, Urszula; Kucwaj-Brysz, Katarzyna; Szamborska-Gbur, Agnieszka; Czardybon, Wojciech; Vilenchik, Maria; Frid, Michael; Kuznetsova, Alexandra; (98 pag.)US2018/179199; (2018); A1;,
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