Related Products of 1211589-43-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211589-43-3, name is 3-Bromo-6-fluoropicolinic acid, molecular formula is C6H3BrFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Para-toluenesulfonyl chloride (27.6 g) was added to a solution of Example 1.4.3 (14.5 g),pyridine (26.7 mL) and tert-butanol (80 mL) in dichloromethane (100 mL) at 0 C. The reaction wasstirred for 15 minutes, warmed to room temperature, and stirred overnight. The solution was concentrated and partitioned between ethyl acetate and Na2C03 solution. The layers were separated,and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, rinsedwith Na2C03 solution and brine, dried over sodium sulfate, filtered, and concentrated to provide thetitle compound.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211589-43-3, 3-Bromo-6-fluoropicolinic acid.
Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; JUDD, Andrew, S.; PHILLIPS, Andrew, C.; SOUERS, Andrew, J.; BRUNCKO, Milan; (503 pag.)WO2017/214301; (2017); A1;,
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