Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5349-17-7, blongs to pyridine-derivatives compound. Product Details of 5349-17-7
General procedure: Potassium carbonate (418 mg, 3 mmol, 1 eq.) was added to a solution of malonitrile (200 mg, 3 mmol, 1 eq.) in dry DMF (5 mL). The reaction was stirred at room temperature for 1 hour and isopropyl isothiocyanate (311 mL, 3 mmol, 1 eq.) was added. After 1 hour stirring at room temperature, 2-bromo-1-(4-methoxyphenyl)ethan-1-one was added (687 mg, 3 mmol, 1 eq.) followed by potassium carbonate (418 mg, 3 mmol, 1 eq.). The mixture was further stirred for 15 hours, and poured into stirring ice/water (50 mL). The resulting precipitate was filtered and washed with water. The title compound was purified by recristalization from hexane/EtOAc and dried under vaccum (823 mg, yield: 87%, purity: 95.7%, Rt = 1.65 min. by method C).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5349-17-7, its application will become more common.
Reference:
Article; Boutard, Nicolas; Sabiniarz, Aleksandra; Czerwi?ska, Klaudia; Jarosz, Ma?gorzata; Cierpich, Anna; Kolasi?ska, Ewa; Wiklik, Katarzyna; Gluza, Karolina; Commandeur, Claude; Buda, Anna; Stasiowska, Agata; Bobowska, Aneta; Galek, Mariusz; Fabritius, Charles-Henry; Bugaj, Marta; Palacz, Edyta; Mazan, Andrzej; Zar?bski, Adrian; Krawczy?ska, Karolina; ?urawska, Ma?gorzata; Zawadzki, Przemys?aw; Milik, Mariusz; W?grzyn, Paulina; Dobrza?ska, Monika; Brzozka, Krzysztof; Kowalczyk, Piotr; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 607 – 613;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem