Electric Literature of 139585-70-9 ,Some common heterocyclic compound, 139585-70-9, molecular formula is C6H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
10 mmol, 1.58 g), Na2CO3 (0.5 mmol, 57 mg), 2-bromo-5-cyanopyridine(0.1 mmol, 115 mg) was dissolved in a mixed solvent of toluene / ethanol / water (V: V = 5: 2: 1). After 24 hours of refluxing, the reaction was stopped and the reaction mixture was left to stand at room temperature , Washed with dichloromethane, and then the organic phase was collected and purified by silica gel column chromatography to obtain 2.1 g of 2- (2 ‘, 4’-difluorophenyl) -5-amidopyridine as a white solid (yield : 89%);
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,139585-70-9, its application will become more common.
Reference:
Patent; UNIVERSITY OF SCIENCE AND TECHNOLOGY OF SUZHOU; ZHOU, YUYANG; WANG, XIAOMEI; YE, CHANGQING; ZHU, SAIJIANG; LIANG, ZUOQIN; (6 pag.)CN104016914; (2016); B;,
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