The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-42-7, name is 6-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-(Trifluoromethyl)picolinic acid
6-Trifluoromethylpyridine-2-carboxylic acid (25 g, 130.8 mmol) was dissolved in 300 mL of methanol, and thionyl chloride (23.3 g, 196.2 mmol) was added dropwise. After addition, the mixture was refluxed for reaction for 12 h. The resultant solution was concentrated untill dry, and saturated sodium hydrogen carbonate solution was added to adjust the pH, and then the resultant was extracted with ethyl acetate, dried over anhydrous sodium sulfate to give the title compound.
With the rapid development of chemical substances, we look forward to future research findings about 131747-42-7.
Reference:
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; LIU, Xiaorong; ZHANG, Yan; HUANG, Dandan; JIANG, Chunhuan; SHI, Xinsheng; GU, Hongfeng; PANG, Silin; HAI, Wei; GE, Bingyang; (71 pag.)EP3489230; (2019); A1;,
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