Synthetic Route of 63725-51-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 63725-51-9, name is 6-Chloro-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate Gen-19-a (5 g, 32.6 mmol, 1 eq) is dissolved in DMF (30 mL). I2 (16.4 g, 64.6 mol, 2 eq) and KOH (6.8 g, 121 mmol, 3.7 eq) are added. The reaction mixture is stirred at rt for 3 h. Then the reaction is quenched with a 10% solution of Na2S2O3. The aqueous layer is extracted four times with 50 mL Et2O, three times with DCM and three times with DCM/ MeOH 9:1. The combined organic layers are dried over Na2SO4, after washing with brine (50 mL), filtered and concentrated to afford Gen-20-a.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63725-51-9, 6-Chloro-1H-pyrazolo[3,4-b]pyridine.
Reference:
Patent; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BONNATERRE, Florence Marie-Emilie; BEAUMONT, Stephane Nicolas Alain; US2015/80391; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem