Synthetic Route of 1462-86-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1462-86-8, name is 3-Aminopicolinic acid. A new synthetic method of this compound is introduced below.
1. Reactions which are covered by Scheme 1; Example 1.1: Preparation of 2-amino-nicotinic acid methyl ester; To a solution of 3-amino-pyridine-2-carboxylic acid (1 g) in methanol (8 ml) and toluene (10 ml), under nitrogen atmosphere, was added a solution of (trimethylsilyl)- diazomethane (3.625 ml) (2M in diethylether). When the effervescence from the reaction had subsided a further portion of (trimethylsilyl)diazomethane (3.625 ml) (2M in diethylether) was added. The reaction mixture was stirred at ambient temperature for 20 hours. The reaction was quenched by addition of acetic acid (0.2 ml). The mixture was concentrated and the residue partitioned between dichloromethane and aqueous potassium carbonate (5% by weight). The phases were separated and the aqueous phase was extracted with further dichloromethane. The combined organic extracts were dried over magnesium sulfate and concentrated to give 2-amino-nicotinic acid methyl ester as a light yellow solid (968 mg). IH-NMR (400 MHz, CDCl3): 8.21-8.23 (m, IH), 8.12-8.14 (m, IH), 6.61-6.64 (m, IH), 3.89 (s, 3H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1462-86-8, its application will become more common.
Reference:
Patent; SYNGENTA LIMITED; WO2009/90401; (2009); A2;,
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