Adding a certain compound to certain chemical reactions, such as: 1603-40-3, 3-Methylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1603-40-3, blongs to pyridine-derivatives compound. Product Details of 1603-40-3
General procedure: 3-Chlorophenyl isothiocyanate and phenyl isothiocyanate (1.9 mmol and 3.7 mmol) was dissolved in 10 mL dichloromethane at 0 C. Then aniline (2.7 mmol and 5.5 mmol), was added dropwise with constant stirring, and completion of reaction is checked by TLC analysis. After 45 min a white solid appeared, the resultant solid product was filtered, washed with hexane, triturated with 10 mL of dichloromethane and excess of hexane and dried under vacuum. Recrystallization with methanol afforded the desired solid thiourea 1-38.
The synthetic route of 1603-40-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Khan, Khalid Mohammed; Naz, Farzana; Taha, Muhammad; Khan, Ajmal; Perveen, Shahnaz; Choudhary; Voelter, Wolfgang; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 314 – 323;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem