Related Products of 1480-65-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1480-65-5 as follows.
[0271] A mixture of 5-chloro-2-fluoropyridine (2 g, 15.21 mmol), N, N-dimethylformamide (40 mL), phenylmethanethiol (2 g, 16.10 mmol), and CS2CO3 (7.52 g, 23.08 mmol) was stirred for 16 h at room temperature. The resulting solution was stirred for 6 h at 60°C. The solids were filtered out. The residue was dissolved in ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by a silica gel column eluting with ethyl acetate/petroleum ether (1 : 10) to afford the title compound (3 g, 83.7percent) as colorless oil. LCMS [M+H+] 236.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1480-65-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; VOLGRAF, Matthew; HU, Baihua; (105 pag.)WO2018/29288; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem