A new synthetic route of 2-Bromo-3-hydroxypyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6602-32-0, 2-Bromo-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 6602-32-0 ,Some common heterocyclic compound, 6602-32-0, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Diisopropyl azodicarboxylate (4.65 mL, 24 mmol) was added slowly to a dioxane(200 mL) solution of 2-bromo-pyridin-3-ol (3.50 g, 20 mmol), 3-aminopropanol (1.67 mL, 22 mmol) and triphenylphosphine (6.30 g, 24 mmol) at 10 0C. After stirring the mixture for 30 min at this temperature, it was refluxed for 18 h Upon cooling, the volatiles were evaporated and the residue was purified by chromatography (silica, 3% MeOH in CH2Cl2 then 5% (2M NH3 in MeOH) in CH2Cl2 to afford the title compound (3.19 g, 69%). 1U NMR (300 MHz, CDCl3, delta): 7.98 (dd, J =4.5, 1.8 Hz, IH), 7.23 (dd, J =4.5, 8.2 Hz, IH), 7.15 (dd, J =I .8, 8.2 Hz, IH), 4.15 (t, J =6.0 Hz, 2H), 2.98 (t, J =6.6 Hz, 2H), 2.00 (m, 2H). MS (ESI): m/e 231 and 233 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6602-32-0, 2-Bromo-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2008/9122; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem