Synthetic Route of 133627-45-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 133627-45-9, name is 2-Chloro-4-methylpyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2-chloro-4-methylpyridin-3-amine [133627-45-9] (3.0 g, 21.0 mmol) in acetic acid (300 mL) was treated with a solution of sodium nitrite (1.45 g, 21.0 mmol) in water (2.5 mL). The reaction mixture was stirred at RT for 24 h. An additional solution of sodium nitrite (500 mg, 7.25 mmol) in water (1 mL) was added to the mixture which was allowed to stir at RT for 3h. Acetic acid was evaporated under reduced pressure and the residual aq. solution was partitioned between EtOAc and sat. aq. NaHCO3. The solid was filtered and dried under vacuum to yield batch 1 of product. The organic filtrate was washed with water and brine, then dried (phase separator) and concentrated to afford batch 2. The two batches were combined to give 7-chloro-iH-pyrazolo[3,4-c]pyridine as a solid. MS (LC/MS): 153 [M+H]+, tR (HPLC conditions d): 0.9 mm.
According to the analysis of related databases, 133627-45-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan Andreas; VULPETTI, Anna; FLOHR, Stefanie; WO2014/2058; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem