New downstream synthetic route of 126053-15-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 126053-15-4, 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126053-15-4, name is 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol

Example A4PXQP ar ation _o_ f intermediate 14 ; Dibromotriphenyl- phosphorane (0.004 mol) was added to a solution of 4-chloro-6,7- dihydro- 5H-Cyclopenta[b]pyridin-7-ol (0.002 mol) in acetonitrile (6 ml). The mixture was stirred for 3 hours, quenched with potassium carbonate 10% and extracted with EtOAc. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated till dryness. The residue (1.6g) was purified by column chromatography over silica gel (15-40 mum) (eluent DCM 100). The pure fractions were collected and the solvent was evaporated till dryness, yielding 0.3 Ig (67%) of intermediate 14.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 126053-15-4, 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/118384; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem