A new synthetic route of 3-Bromo-2-formylpyridine

Statistics shows that 405174-97-2 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-formylpyridine.

Synthetic Route of 405174-97-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.405174-97-2, name is 3-Bromo-2-formylpyridine, molecular formula is C6H4BrNO, molecular weight is 186.0061, as common compound, the synthetic route is as follows.

A mixture of B6.1 (480 mg, 2.58 mmol ) in MeOH(10 mL) and THF(5 mL) was cooled to 0 oC , NaBH4 (390 mg, 10.32 mmol) was added in portions .The mixture was stirred for 4 h, then concentrated, and diluted with water(30 mL), extracted with DCM (30 mL × 3). The organic layer was washed with brine (30 mL), dried over Na2SO4, concentrated to give the title compound (400 mg, 82%) as a white solid. LC-MS: [MH]+ = 188.0.

Statistics shows that 405174-97-2 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-formylpyridine.

Reference:
Patent; NOVARTIS AG; CHAN, Ho Man; FU, Xingnian; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue; ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (193 pag.)WO2017/221092; (2017); A1;,
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