Application of 156270-06-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 156270-06-3, name is 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid. A new synthetic method of this compound is introduced below.
A mixture of trans-3- (2- (1- (4-amino) cyclohexyl) ethyl)-7-cyano-2, 3,4, 5-tetrahydro- 1 H 3-benzazepine (103 mg, 0.35 mmol), 3-pyrrol [2,3-b] pyridyl carboxylic acid (56 mg, 0.35 mmol), 1- (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (67 mg, 0.35 mmol) and 1-hydroxybenzotriazole (20 mg, 0.15 mmol) in dichloromethane (8 ml) was shaken at room temperature for 16 h. The reaction mixture was washed with saturated aqueous sodium bicarbonate (4 ml). The resulting precipitate was collected by filtration, washed with water (2 x 10 ml) and dried to give the title compound (81 mg, 0.18 mmol, 53percent) as a colourless solid. Mass spectrum (API+) : Found 442 (MH+). C27H31N5O requires 441. 1 H NMR (DMSO-d6) 8 : 1.02 (2H, m), 1.15-1. 45 (6H, m), 1.81 (4H, m), 2.50 (5H, m), 2.91 (4H, m), 3.73 (1H, m), 7.14 (1H, m), 7.32 (1H, d, J = 8 Hz), 7.57 (2H, m), 7.73 (1H, d, J = 8 Hz), 8.16 (1H, m), 8.25 (1H, m), 8.42 (1H, m), 12.03 (1H, br s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,156270-06-3, 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/94835; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem