Application of 571189-16-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 571189-16-7 as follows.
A suspension of 2 and 10% palladium on carbon in ethanol was hydrogenated for 2 h. The reaction mixture was filtered through celite and concentrated in vacuo to give 3 as brown oil. 1H NMR (400 MHz, DMSO-d6): delta 7.77-7.76 (d, J = 2.1 Hz, 1H, ArH), 7.27-7.14 (dd, J = 3.0 Hz, 1H, ArH), 6.51 (d, J = 9.0 Hz, 1H, ArH), 3.61-3.59 (m, 4H, piperazine-CH2), 3.39-3.36 (m, 4H, piperazine-CH2), 1.48 (s, 9H. t-butyl-CH3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,571189-16-7, its application will become more common.
Reference:
Article; Sharath Kumar, Kothanahally S.; Hanumappa, Ananda; Hegde, Mahesh; Narasimhamurthy, Kereyagalahally H.; Raghavan, Sathees C.; Rangappa, Kanchugarakoppal S.; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 341 – 349;,
Pyridine – Wikipedia,
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