Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18368-64-4, name is 2-Chloro-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-methylpyridine
In a 1000 mL flask 450 g of chlorobenzene, 100 g of 2-chloro-5-methylpyridine and 3 g of cobalt acetate were added with stirring. The temperature of the heating system was raised to 80° C and the flow rate of oxygen was controlled at 0.4 L / Min and under these conditions the reaction was carried out for 4 hours. After completion of the reaction, the system was cooled to room temperature, filtered and dried to give 119 g of a mixture of 6-chloronicotinic acid and cobalt acetate. The above resulting mixed crude product was placed in a 1000 mL flask, then added 600 g of recrystallized solvent methanol, stirring heated to reflux until all the crude 6 – chloro nicotinic acid was dissolved, after 5 min of incubation, the system slowly cooled to 5°C, white crystal was precipitated, the stirring was continued for 1 hour while maintaining the internal temperature , then carried out flirtation , the filter cake was washed once with a small amount of cooled methanol and obtained product was dried at 80°C for 4 hours to obtain 98.5 g of 6-chloronicotinic acid, Purity 99. 52percent (HPLC), yield 79.7percent( Do not count the remaining product in the mother liquor, followed by a slightly written as “excluding the mother liquor”).
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Reference:
Patent; CHANGSHU LEAGUE CHEMICAL CO LTD; CHEN, HUA; (6 pag.)CN103570612; (2016); B;,
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