Application of 105250-17-7 ,Some common heterocyclic compound, 105250-17-7, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of (2-aminopyridin-4-yl)methanol (5.00 g, 40.3 mmol) and aqueous hydrobromic acid (50 mL, c =. 48 percent , 440 mmol) was heated at 100D for 24 hours. The mixture was cooled to room temperature and concentrated under reduced pressure. Ethyl acetate was added to the crude product and the resulting solid was filtered, washed with ethyl acetateand dried under reduced pressure to give 7.70 g (71 percent) of the title compound as a crude product that was used without further purification.LC-MS (Method 2): R = 0.68 mm; MS (ESIpos): m/z = 186; 188 [M+H]1H-NMR (400 MHz, d6-DMSO): oe [ppm] = 8.10 (brs, 2H), 7.90 (d, J = 6.9 Hz, IH), 6.98 (s,1 H), 6.84 (dd, J = 1.8 and 6.9 Hz, 1 H), 4.65 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,105250-17-7, its application will become more common.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Pyridine – Wikipedia,
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