Reference of 1235865-75-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1235865-75-4, name is Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate. A new synthetic method of this compound is introduced below.
In 100mL2-Boc-octahydropyrrolyl [3,4-c] pyrrole (0.73 g, 3.4 mmol), 2-((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4-fluorobenzoic acidMethyl ester (1.00 g, 3.8 mmol), dipotassium hydrogen phosphate(2.28 g, 10 mmol) and 40 mL of DMSO were reacted at 130 C. for 6 h, cooled to room temperature, 50 mL of water and 30 mLEA, the layers were separated, the aqueous layer was extracted twice with 50 mL of EA, the combined organic phases were washed once with 50 mL of saturated brine,Dried over sodium sulfate, filtered and spin-dried to give 0.702 g of product in 43% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235865-75-4, Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Sun Yat-sen University; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Kou Yuhui; Hu Bolin; Jiang Haigang; Ye Jiuyong; Liu Zhiqiang; Xie Hongming; Zhang Yingjun; Yan Ming; (39 pag.)CN106749233; (2017); A;,
Pyridine – Wikipedia,
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