Related Products of 884495-03-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 884495-03-8, name is 3-Amino-2-bromo-5-fluoropyridine. A new synthetic method of this compound is introduced below.
Ethynyltrimethylsilane (0.82 mL, 6.3 mmol) was added dropwise to a stirred mixture of 2-bromo-5-fluoropyridin-3-amine (1.0 g, 5.23 mmol), Pd(PPh3)2Cl2 (0.18 g, 0.26 mmol) and Cul (50 mg, 0.26 mmol) in triethylamine (15 mL) at 0C. The reaction was stirred for 4 h at rt under nitrogen. The mixture was concentrated under reduce pressure. The residue was purified by silica gel column chromatography (PE/EA, from 20/1 tolO/1) to give compound 23 (0.8 g, 73% yield). LC-MS: 209.16 (M+H), Ci0Hi3FN2Si. 1H NMR (CDC13, 400 MHz) 0: 7.83 (s, 1H), 6.75-6.72 (m, 1H), 4.40 (br, 2H), 0.28 (s, 9H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,884495-03-8, 3-Amino-2-bromo-5-fluoropyridine, and friends who are interested can also refer to it.
Reference:
Patent; AKARNA THERAPEUTICS, LTD.; MOHAN, Raju; PRATT, Benjamin, Anthony; (297 pag.)WO2016/103037; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem