Reference of 16179-97-8 ,Some common heterocyclic compound, 16179-97-8, molecular formula is C7H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A suspension of 2-pyridineacetic acid hydrochloride (Aldrich; 1.74 g, 10 mmol) and carbonyl diimidazole (1.95 g, 12 mmol) in anhydrous THF (20 mL) was stirred at rt for 1 h. To the mixture was added solid 4-chloroaniline (1.28 g, 10 mmol). After stirring overnight, the solvent was removed and the residue was partitioned between water and EtOAc. The organic layer was dried over Na2SO4 and evaporated to dryness. The crude product was recrystallized from 20 mL of toluene affording 1.5 g (60%) of the amide as a solid. TOF MS ES+ m/z 247 (MH+), 269 (M+Na+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.; US2006/293329; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem