Synthetic Route of 1072-97-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1072-97-5 as follows.
Step-1: Synthesis of ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate To a stirred solution of 5-bromopyridin-2-amine (10.0 g, 56.0 mmol, 1.0 eq.) and ethyl 3-bromo-2-oxopropanoate (12.6 g, 64.0 mmol, 1.1 eq.) in Dioxane (200 mL) was added MgSO4 (20.0 g, 150.0 mmol, 3.0 eq.) at RT. The resulting mixture heated to 80 C. for 16 h. Following this, reaction mixture cooled to RT filtered the solid and under vacuum and filtrate concentrated to get crude. The crude purified by normal phase silica-gel column to get title compound (12 g, 79%). LCMS: 269.9 [M+1]+; 1H NMR (400 MHz, DMSO-d6) delta ppm 8.91 (d, J=1.32 Hz, 1H) 8.47 (s, 1H) 7.62 (d, J=9.65 Hz, 1H) 7.47 (dd, J=9.65, 1.75 Hz, 1H) 4.31 (q, J=7.16 Hz, 2H) 1.31 (t, J=7.02 Hz, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1072-97-5, its application will become more common.
Reference:
Patent; INTEGRAL BIOSCIENCES PRIVATE LIMITED; CHAKRAVARTY, Sarvajit; PENDHARKAR, Dhananjay; RAMACHANDRAN, Sreekanth A.; BATHULA, Chandramohan; SONI, Sanjeev; KUMAR, Vivek; SAEED, Uzma; DANODIA, Abhinandan Kumar; SHARMA, Ankesh; JADHAVAR, Pradeep S.; US2020/206233; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem