New downstream synthetic route of 1597-33-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1597-33-7, 2-Fluoropyridin-3-amine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1597-33-7, name is 2-Fluoropyridin-3-amine, molecular formula is C5H5FN2, molecular weight is 112.11, as common compound, the synthetic route is as follows.SDS of cas: 1597-33-7

To a solution of the corresponding amines (1 equiv.) in dichloromethane was added pyridine (1 equiv.) and phenyl chloroformate (1 equiv.) at 0 C. Stirring was continued for 2 h followed by the addition of the scaffold amine (1 equiv.) and DMAP (0.2 equiv.). The reaction mixture was refluxed overnight. After cooling, water was added and extracted with dichloromethane. The pooled organic fractions were brine washed, dried, concentrated and purified by Reverse Phase Prep-HPLC to provide compounds A6.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1597-33-7, 2-Fluoropyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco Gerald; SAUNDERS, Jeffrey Owen; TRAVINS, Jeremy; YAN, Shunqi; WO2014/62511; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem