Application of 153034-78-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-78-7, name is 2-Fluoro-3-iodo-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
In a 20-ml flask, 2-fluoro-3-iodo-5-methylpyridine (1.0 g, 4.2 mmol), potassium acetate (828 mg, 8.4 mmol), acetic acid (1 ml) and aniline (393 mg, 4.2 mmol) were mixed, and the solution was heated to reflux for 10 hours. After allowing the solution to stand overnight at room temperature, aniline (393 mg, 4.2 mmol) was added, and the mixture was further heated to reflux for 10 hours. After allowing the mixture again to stand overnight at room temperature, aniline (393 mg, 4.2 mmol) was added, and the mixture was further heated to reflux for 8 hours. This reaction solution was cooled to room temperature, ethyl acetate (20 ml) was added thereto. The organic layer was separated and washed with water (5 ml) two times. The organic layer was washed twice with a saturated aqueous sodium bicarbonate solution (10 ml) and further washed with saturated brine (10 ml) . The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure, diisopropyl ether (about 50 ml) was added to the residue, and a precipitate was filtered off. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (hexane : ethyl acetate = 4:1). The obtained extract was concentrated under reduced pressure, and dried under reduced pressure at 50C, to yield the title compound (539 mg, 1.7 mmol) as a yellow oily material (yield 41.2%) . 1H-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 2.17 (s, 3H), 6.77 (brs, IH), 6.98-7.03 (m, IH), 7.28-7.34 (m, 2H), 7.53-7.57 (m, 2H), 7.77-7.79 (s, 2H), 7.96-7.97 (m, IH).13C-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 17 . 04 , 81 . 16, 119.57 , 122 .48 , 125.72 , 128. 99, 140. 60, 147 .20, 147 .93, 151 . 92 High resolution mass spectrometry (Ci2HiIlN2 )Theoretical value : 308 .9889 [M-H] + Measured value : 309. 9892 [M-H] +
According to the analysis of related databases, 153034-78-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/16184; (2008); A1;,
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