Related Products of 944401-65-4, Adding some certain compound to certain chemical reactions, such as: 944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine,molecular formula is C5H4BrFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944401-65-4.
A solution of sodium nitrite (21.67g, 314.13mmol) in water (150mL) was added dropwise to a stirred mixture of 5-bromo-6-fluoropyridin-2-amine (50g, 261.78mmol) and sulphuric acid (1.2mL, 22.51mmol) in water (750mL) at 0-5C. The resulting suspension was stirred for 48 h at ambient temperature then the precipitate collected by filtration, washed with water (200mL) and dried under vacuum to afford the desired material (40. Og, 80%) as a pale yellow solid, which was used without further purification. NMR Spectrum: 1H NMR (300MHz, DMSO-d6) delta 6.55 (1H, d), 8.00 (1H, t), 11.71 (1H, bs). Mass Spectrum: m/z (ES+)[M+H]+ = 192.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 944401-65-4, 5-Bromo-6-fluoropyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARLAAM, Bernard Christophe; PIKE, Kurt Gordon; WO2015/170081; (2015); A1;,
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