Synthetic Route of 1196155-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1196155-38-0, name is 2-Chloro-6-(trifluoromethyl)isonicotinonitrile, molecular formula is C7H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of methyl 3,5-dihydroxybenzoate 2 (163 mg, 0.97 mmol) in DMF (10 mL) at RT, were added K2C03 (161 mg, 1.16 mmol) and 2-chloro-6- (trifluoromethyl)isonicotinonitrile 1 (200 mg, 0.97 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was quenched with water (20 mL) and extracted with EtOAc (2 x 20 mL), and the combined organic extracts were washed with brine (10 mL), dried (Na2S04), filtered and concentrated. The residue was purified (silica gel; eluting 20-25percent EtOAc/hexanes) to afford compound 3 (110 mg, 34percent) as a white solid. 1H NMR (500MHz, CDC13): delta 7.59 (s, 1H), 7.41 – 7.44 (m, 2H), 7.36 (s, 1H), 6.90 (br s, 1H), 3.91 (s, 3H); LCMS Mass: 339.1 (M++l).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1196155-38-0, 2-Chloro-6-(trifluoromethyl)isonicotinonitrile.
Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin W.; HUTCHINSON, John Howard; CALDERON, Imelda; (202 pag.)WO2016/144703; (2016); A1;,
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