Related Products of 884494-54-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884494-54-6 as follows.
Step A N-r(2-chloro-5-fluoropyridin-4-yl’)methylidenel-2-methylpropane-2-sulfinamide (1-8); A solution of 2-cMoro-5-fluoroisonicotinaldehyde (1-7, 5.0 g, 31.34 mmol), 2-methyl-2- propanesulfmamide (4.18 g, 34.47 mmol) and Ti(OEt)4 in THF (50 ml) was heated at 60 0C for 18 h. The reaction mixture was cooled to -20 0C and then 60 ml MeOH was added. The cooling bath was removed. CELITE was then added followed by a 200 ml brine wash. The resulting solids were filtered through a fritted glass funnel and washed with EtOAc. The organic portion was separated, dried (MgSO4) and concentrated in vacuo. Chromatography (hexanes to 50% EtOAc/hexanes) afforded 1-8.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-54-6, its application will become more common.
Reference:
Patent; MERCK & CO., INC.; WO2007/16358; (2007); A1;,
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