Related Products of 147269-67-8 , The common heterocyclic compound, 147269-67-8, name is Benzyl (2-oxo-1,2-dihydropyridin-3-yl)carbamate, molecular formula is C13H12N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of benzyl (2-oxo-1,2-dihydropyridin-3-yl)carbamate (3.17 g, 12.96 mmol) in 1,4-dioxane (150 mL) under nitrogen atmosphere, NaH (0.5 19 g, 12.96 mmol) was added and kept stir at rt for 10 mi 2-chloro-5-fluoro-4-methylpyrimidine (1.9 g, 12.96 mmol) was added and heated in a pressure tube at 110 C for 24h. Thereaction mixture was concentrated under vacuum to remove the solvent. To the crude resiude was extracted with EtOAc (50 mL) and water (50 mL). The aq. layer was further extracted with EtOAc (3 x 5OmL) and the combined organic layer was washed with brine (50 mL), dried over sodium sulfate. The desired product benzyl (1-(5-fluoro-4- methylpyrimidin-2-yl)-2-oxo- 1 ,2-dihydropyridin-3 -yl)carbamate (300 mg, 0.820 mmol,6.32 % yield) was isolated as a brown solid by ISCO (24g silica gel, solid loading, 40-100% ethyl acetate/pet ether).
The synthetic route of 147269-67-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
Pyridine – Wikipedia,
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