Application of 74420-15-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 74420-15-8, name is 3-Bromo-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.
Example 1G3-Bromo-1-(phenylsulfonyl)-1H-pynolo[2,3-b]pyridineTo a 0 C. solution of EXAMPLE 1F (25 g, 127 mmol) in N,N-dimethylformamide (200 mL) was slowly added sodium hydride (3.37 g, 133 mmol) over several minutes. After stirring for 30 minutes in the cold water bath, benzenesulfonyl chloride (17.18 ml, 133 mmol) was added via a syringe. The solution was allowed to warm to room temperature overnight, quenched slowly with 500 mL water, stirred for 30 minutes, and then filtered. The solid obtained was washed with water, followed by 300 mL of hexanes, dried over high-vacuum for 16 hours to give the title compound which was used without further purification. MS (ESL) m/z 338.7 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74420-15-8, its application will become more common.
Reference:
Patent; ABBOTT LABORATORIES; US2011/257187; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem