With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18437-58-6, name is 4-Amino-2-picoline, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives
To a solution of (E)-methyl 3-(2-(2-chloropyrimidin-5-yl)vinyl)-4-fluoro- 5-methoxybenzoate (232 mg, 0.72 mmol) in 1,4-dioxane (12 mL) were added 2-methylpyridin-4-amine (93 mg, 0.86 mmol), palladium( II )acetate (16 mg, 0.072 mmol), Xantphos (83 mg, 0.14 mmol) and Cs2C03 (703 mg, 2.16 mmol). Then the mixture was stirred under microwave at 150C for 20 min. The mixture was then concentrated and purified via ISCO (eluted with MeOH in DCM 0%~15%) directly to give a yellow solid (143 mg, 50.4% yield). MS (m/z): 395.1 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18437-58-6, 4-Amino-2-picoline, and friends who are interested can also refer to it.
Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; ZHANG, Weihan; LI, Jinshui; WO2014/139465; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem