Adding a certain compound to certain chemical reactions, such as: 4548-45-2, 2-Chloro-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4548-45-2, blongs to pyridine-derivatives compound. Recommanded Product: 2-Chloro-5-nitropyridine
To a stirring solution of compound 20 (5.0 g, 31.5 mmol) in acetic acid (50 ml) was added iron powder (8.8 g, 157.6 mmol) in small portion at room temperature, the reaction was exothermic and the temperature rise to 80C, end of added and kept the temperature at 40-50C and stirred for 2h. The reaction was filtered through celite and washed with little acetic acid, the filtrate was evaporated to dryness, adjusted pH=8 with saturated solution of sodium bicarbonate, extracted with dichloromethane (100 ml x 5). The combined organic phase was washed with brine, dried over Na2S04, filtered and concentrated to afford crude compound 84 (3.9 g, yield 96%) as a brown solid, used directly in next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4548-45-2, its application will become more common.
Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin; YANG, Heping; YU, Yajun; WO2013/91502; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem