Synthetic Route of 10201-73-7 ,Some common heterocyclic compound, 10201-73-7, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a mixture of 2-aminopyridine (0.5 mmol, 1 equiv), p-TSA (0.4 mmol,0.8 equiv), 1-butylpyridinium bromide (1.5 mmol, 3 equiv) in a 50 mL Schlenk tube were added 1,2-dimethoxyethane (2 mL) under air. Then H2O2 (1.2 mmol, 2.4 equiv) was added. The mixture was stirred at 80C for 24 h. And then the mixture was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the products.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10201-73-7, 2-Amino-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xu, Tong; Zhou, Wen; Wang, Jing; Li, Xue; Guo, Jun-Wen; Wang, Bin; Tetrahedron Letters; vol. 55; 36; (2014); p. 5058 – 5061;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem