Reference of 139042-59-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.139042-59-4, name is 5-Acetyl-2-bromopyridine, molecular formula is C7H6BrNO, molecular weight is 200.03, as common compound, the synthetic route is as follows.
A mixture of compound J-1 (25 g, 125.6 mmol), NBS (24.5 g, 138.2 mmol) and p-TSA (3.4 g, 20.9 mmol) wasstirred at 100 C under N2 for 2 hours. The mixture was then cooled to rt and dissolved in DCM. The resulting mixturewas quenched with water and extracted with DCM (50 mL x 3). The combined organic phases were dried over anhydrousNa2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) =5/1) to give the title compound J-2 (25 g, 71%). The compound was characterized by the following spectroscopic data:MS-ESI: m/z 279.9 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 8.95 (d, J = 1.12 Hz, 1H), 8.11-8.14 (m, 1H), 7.66-7.68 (m, 1H), 4.41 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 139042-59-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); B1;,
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