Application of 800401-67-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 800401-67-6, name is Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, molecular formula is C10H9ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Route A: To a solution of 5-chloro-lH-pyrrolo [2,3-c] pyridine-2-carboxylic acid ethyl ester (Preparation 17,1. 78g, 7. 9MMOL) in ethanol (70mL) was added sodium hydroxide solution (5.2mL, 2M, 10. 3MMOL) and the mixture heated under reflux for 2h. The solvent was removed in vacuo and the solid dissolved in water (150ML) and acidified to pH 4 with acetic acid to give the title compound as a brown solid that was isolated by filtration. ON (CD30D): 7.13 (1H, s), 7.68 (1H, s), 8. 58 (1H, s); M/Z (ES+) =197 [M+H] +
According to the analysis of related databases, 800401-67-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem