As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113975-31-8, name is N-(3-Iodopyridin-2-yl)pivalamide, molecular formula is C10H13IN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of N-(3-Iodopyridin-2-yl)pivalamide
3-Iodopyridin-2-amine N-(3-iodopyridin-2-yl)pivalamide (13.80 g, 45.36 mmole) was taken up in H2SO4 (24 wt. %, 394 ml) and the mixture was stirred for 60 minutes under reflux. After cooling to RT the mixture was neutralised with 4 N NaOH and solid NaHCO3, the aqueous phase was extracted with DCM (3*200 ml), and the combined organic phases were dried over MgSO4. After filtration, the solvent was removed on a rotary evaporator. 3-iodpyridin-2-amine (9.70 g, 97%) was obtained as a cream-coloured solid.
With the rapid development of chemical substances, we look forward to future research findings about 113975-31-8.
Reference:
Patent; GRUNENTHAL GMBH; US2009/156593; (2009); A1;,
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