Reference of 132330-98-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 132330-98-4, name is 3-(Benzyloxy)-2-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.
TFA (30 mL) was placed in the round-bottom flask equipped with a magneticstirred, and the reaction mixture was cooled to 0 C under Ar. Then, tert-butyl(mesitylsulfonyl)oxycarbamate (6.34 g, 20.00 mmol) was added portionwise over 5 mm, and the reaction mixture was stirred at 0 C for 1 h under Ar. Afterwards, the reaction mixture was quenched with ice water (100 mL), producing white solid. The reaction mixture was diluted with cold water (150 mL), the solid was filtered off, and was washedwith cold water until pH7.0. The obtained solid was dissolved in DCM (75.0 mL), and was stirred with Na2SO4 at 0 C for 15 mm to remove water. Afterwards, Na2SO4 was removed by filtration, and the DCM solution was added to a cooled (ice bath) solution of 3-(benzyloxy)-2-bromopyridine (4.41 g, 16.1 mmol) in DCM (25 mL). The reaction mixture was stirred at 0 C for 2 h. Then, ice bath was removed, and the reaction mixturewas allowed to reach rt and was stirred at this temperature for 1 h. Solvent was removed under reduced pressure, the residue was dissolved in DMF (100 mL), then methyl propiolate (2.86 mL, 32.1 mmol) and K2C03 (6.66 g, 48.2 mmol) were added sequentially. The obtained suspension was stirred at rt for 16 h. The reaction mixture was diluted with EtOAc (500 mL), washed with water (3×250 mL), brine (1×250 mL), dried(Na2504) and filtered. The residue was purified by flash chromatography to give Intermediate 47 (0.88 g, 15% yield) as an off-white solid. MS(ESI) m/z: 260.8 (M+H)?H NMR (300MHz, CDC13) oe ppm 8.45 (s, 1H), 8.15 (d, J=9.6 Hz, 1H), 7.48-7.16 (m, 6H), 5.24 (s, 2H), 3.91 (s, 3H).
According to the analysis of related databases, 132330-98-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
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