Application of 754131-60-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine. A new synthetic method of this compound is introduced below.
A solution of tert-butyl4-hydroxypiperidin-1-carboxylate (9.63 g) in THF (100 ml)was cooled to 0C, 60% sodium hydride (3.19 g) was added, and the mixture wasstirred for 20 min. To the reaction mixture was added a solution of3-bromo-2-(bromomethyl)pyridine (10.00 g) in THF (100 ml), and the mixture wasstirred at room temperature under an argon atmosphere overnight. To the mixture wasadded water at 0C, and the mixture was extracted with ethyl acetate. The organic layerwas washed with water and saturated brine, dried over anhydrous magnesium sulfate,and the solvent was evaporated under reduced pressure. The residue was purified bysilica gel chromatography (ethyl acetate/hexane) to give the title compound (13.12 g).MS, found: 371.1,373.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,754131-60-7, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem