Electric Literature of 1246349-97-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1246349-97-2, name is 4-Chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine, molecular formula is C14H11ClIN3O, molecular weight is 399.61, as common compound, the synthetic route is as follows.
Intermediate 14 Cyclohexyl-[3-iodo-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-4-yl]-amine To a solution of Intermediate 13 (0.95 g, 2.4 mmol) in 1-butanol (5 ml) at room temperature was added cyclohexylamine (1.1 ml, 9.52 mmol). The resulting mixture was irradiated at 190 0C for 1 h in a Biotage I-60 microwave reactor. The reaction mixture was then evaporated to dryness and the crude residue was purified by flash chromatography eluting with 10 to 100% ethyl acetate/petroleum ether gradient to give a white solid (0.87 g, 80%) 1H NMR (400 MHz1 DMSO-d6) delta ppm 1.24 – 1.50 (m, 5 H), 1.50 – 1.63 (m, 1 H), 1.63 – 1.80 (m, 2 H), 1.86 – 2.03 (m, 2 H), 3.72 (s, 3 H), 4.02 – 4.15 (m, 1 H), 5.43 (s, 2 H), 5.95 (d, .7=7.3 Hz, 1 H), 6.85 – 6.90 (m, 2 H), 6.95 (d, J=6.0 Hz, 1 H), 7.15 – 7.24 (m, 2 H), 7.76 (d, J=6.0 Hz, 1 H); m/z (ES+APCI)+: 463 [M + H]+.
Statistics shows that 1246349-97-2 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; SMILJANIC, Ela; HARDING, Denise, Jamilla; HOUGH, Joanne; WO2010/106333; (2010); A1;,
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