The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H12N2O
[01751 ] The above acid (0.6 g, 2.2mmol) was then dissolved in DMSO (5 mL) and 3-(amino methyl)-4, 6-dimethylpyridin-2(l H)-one (0.67 g, 4.44 mmol) was added. The reaction mixture was stirred at room temperature for 1 5 min before PYBOP ( 1 .7 g, 3.33 mmol) was added and stirring was continued overnight. After completion of the reaction, the reaction mass was poured into ice; extraction was carried out using 10 % MeOH/DCM. The combined organic layers were dried over sodium sulphate and concentrated under reduced pressure to obtain crude material which was then purified by solvent washings giving the title compound (0.45 g, 50%). LCMS:402.20 (M + 1 )+; HPLC: 98.73% ((at) 254 nm) (R,;4.096; Method: Column: YMC ODS-A 150 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Inj . Vol: 10 mu, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1.5 min, 9.51 -12 min 5% B); ‘H NMR (DMSO-<¾, 400 MHz) delta 1 1 .47 (s, 1 H), 8.22 (t, 1 H, J=4.4 Hz), 6.97 (s, 1 H), 6.92 (s, 1 H), 5.85 (s, 1 H), 4.23 (d, 2H, J=4.4 Hz), 3.75-3.79 (m, 1 H), 2.87-2.93 (m,2H), 2.18 (s, 3H), 2.15 (s, 3H), 2.10 (s, 3H), 1 .99 (m, 2H), 1 .58- 1 .69 (m, 4H), 0.77 (t, 3H, J=6.8 Hz).
With the rapid development of chemical substances, we look forward to future research findings about 771579-27-2.
Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
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