Adding a certain compound to certain chemical reactions, such as: 823-56-3, 2-Fluoro-3,5-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2Cl2FN, blongs to pyridine-derivatives compound. Formula: C5H2Cl2FN
Example 11 Preparing 2,3-difluoro-5-chloropyridine by Reacting 2-fluoro-3,5-dichloropyridine Using tetrakis(diethylamino)phosphonium bromide A 500 ml four-necked flask which is equipped with thermometer, anchor stirrer and reflux condenser with bubble counter is charged with 166 g (1 mol) of 2-fluoro-3,5-dichloropyridine, 68.4 g (1.2 mol) of potassium fluoride and 3.99 g (0.01 mol) of tetrakis(diethylamino)phosphonium bromide. The reaction mixture is then heated with stirring to the predetermined reaction temperature and is allowed to react for the time indicated. After the end of the reaction the reaction mixture is cooled and poured into water which is employed in excess, the mixture is subjected to extraction with methylene chloride, and the isolated methylene chloride phase is washed with water, dried and then subjected to fractional distillation under reduced pressure.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,823-56-3, 2-Fluoro-3,5-dichloropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Aventis Research & Technologies GmbH & Co.; US6184425; (2001); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem