Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15128-82-2, name is 2-Nitropyridin-3-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N2O3
To an ice-cold solution of 2-nitropyridin-3-ol (10.0 g, 71 mmol) and triethylamine (14.9 ml, 107 mmol) in methylene chloride (150 ml) was added, dropwise, triflic anhydride (14.5 ml, 86 mmol) and the mixture was stirred for 2h. Water was added and the mixture extracted with methylene chloride. The organic phase was dried with sodium sulfate and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel using n-heptane/ethyl acetate (v/v 2:8 to 3:7) as eluent. The title compound was obtained as a light brown liquid (18.4 g, 95%).MS ISP (m/e): 273.1 [(M+H)+].1H NMR (CDCI3, 400 MHz): delta (ppm) = 8.65 (dd, 1H), 8.00 (dd, 1H), 7.80 (dd, 1H).
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew; WO2011/92272; (2011); A1;,
Pyridine – Wikipedia,
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