With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24242-20-4, name is 5-Aminopicolinic acid, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.Quality Control of 5-Aminopicolinic acid
5-Amino-pyridine-2-carboxylic acid 1 (5.4 mmol) is dissolved in benzene : MeOH = 3 :1 (40 niL) and cooled in an ice-bath to 00C. To the solution is slowly added 2M TMSCH2N2 in Et2O solution (6.5 mmol). After the addition is complete, the reaction mixture is warmed to rt and stirred for 6 h. After removing the solvent in vacuum, methyl 5-aminopicolinate 2 is obtained and used in the next step without further purification. MS (m/z) (M+l)+: 153.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,24242-20-4, 5-Aminopicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; IRM LLC; WO2009/26204; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem