Sources of common compounds: 4-Aminonicotinic acid

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7418-65-7, name is 4-Aminonicotinic acid. A new synthetic method of this compound is introduced below., Quality Control of 4-Aminonicotinic acid

Example 88; 7V-Methyl-4-(2-(2-oxoindolin-5-ylaniino)-5-(trifluoromethyl)pyridin-4- ylamino)nicotinamide; 4-Amino-lambda’-inethylnicotinamide; To the mixture of 4-aminonicotinic acid (691 mg, 5.0 mmol), methylamine hydrogen chloride (410 mg, 1.2 eq), EDC (1.15 g, 1.2 eq), HOBt (810 mg, 1.2 eq) in DMF (2OmL) was added DIEA (3.0 mL, 3.0 eq). The mixture was stirred at room temperature overnight. It was concentrated and dissolved in EtOAc. It was washed with saturated NaHCO3 solution. It was concentrated and purified by silica gel with chromatography (0%~20% MeOH/DCM) to obtain the desired product 4-amino-7V- methylnicotinamide.

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Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2008/115369; (2008); A2;,
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