Application of 38496-18-3, Adding some certain compound to certain chemical reactions, such as: 38496-18-3, name is 2,6-Dichloronicotinic acid,molecular formula is C6H3Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38496-18-3.
To a stirred solution of 292 2,6-dichloronicotinic acid (20.0 g, 104.16 mmol, 1.0 eq) in 165 THF (80 mL) and 30 MeOH (40 mL) was added LiOH.H2O (13.11 g, 312.49 mmol, 3.0 eq) at rt. The resulting mixture was stirred at same temperature for 12 h. Progress of reaction was monitored by LCMS. After completion of reaction, mixture was concentrated and diluted with water (100 mL), followed by dropwise addition of 1N 31 HCl (50 mL), the formation of white precipitate was observed which was filtered and dried under vacuum to afford 293 6-chloro-2-methoxynicotinic acid as white solid (19.0 g, 97.23%). (0415) LCMS: 188 [M+1]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38496-18-3, 2,6-Dichloronicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem