Adding a certain compound to certain chemical reactions, such as: 73290-22-9, 2-Bromo-5-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3BrIN, blongs to pyridine-derivatives compound. Computed Properties of C5H3BrIN
To a solution of 2-bromo-5-iodopyridine (1.00 g, 3.52 mmol), tert-butyl (R)-(3H- spiro[benzofuran-2,4′-piperidin]-3-yl)carbamate (1.09 g, 3.52 mmol, Intermediate EB) and Cs2C03 (3.44 g, 10.6 mmol) in toluene (10.0 mL) was added XantPhos-Pd-G4 (339 mg, 352 umol). The mixture was stirred at 80 C for 12 h. The mixture was then filtered and the filtrate was concentrated under reduced pressure to give a residue. The residue was purified by Pre-HPLC (column: Phenomenex Synergi C18 250*50*l0um; mobile phase: [water (0.05%ammonia hydroxide v/v)-ACN]; B%: 46%-7l%, 36min, 80%min) to give (R)-N- ((R)-r-(6-bromopyridin-3-yl)-3H-spiro[benzofuran-2,4′-piperidin]-3-yl)-2-methylpropane-2- sulfmamide (570 mg, 1.23 mmol, 35% yield) as a white solid. LC-MS (ESI+) m/z 466.1 (M+H)+; 1HNMR (400 MHz, CDCl3): d 8.04 (d, J = 3.20 Hz, 1H), 7.31-7.29 (m, 3H), 7.14-7.11 (m, 1H ), 7.56-7.53 (m, 2H), 6.96-6.95 (m, 1H), 6.85 (d, J = 8.00 Hz, 1H), 4.73 (d, J = 10.8 Hz, 1H), 3.72 (d, J = 10.8 Hz, 1H), 3.66-3.53 (m, 2H), 3.26-3.22 (m, 2H), 2.28-2.16 (m, 1H), 2.16-2.13 (m, 1H), 1.96-1.83 (m, 2H), 1.28 (s, 9H).
The synthetic route of 73290-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
Pyridine – Wikipedia,
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