Extracurricular laboratory: Synthetic route of 1H-Pyrrolo[2,3-b]pyridine-2,3-dione

Statistics shows that 5654-95-5 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-b]pyridine-2,3-dione.

Synthetic Route of 5654-95-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5654-95-5, name is 1H-Pyrrolo[2,3-b]pyridine-2,3-dione, molecular formula is C7H4N2O2, molecular weight is 148.1189, as common compound, the synthetic route is as follows.

To a THF solution of E1 and RI-Br (R1 = alpha-methyl-p-fluorobenzyl) will be added NaH (1.1 eq) and the solution will be heated until the starting material disappears. After removal of volatiles, the residue will be chromatographed to give compound E2.

Statistics shows that 5654-95-5 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-b]pyridine-2,3-dione.

Reference:
Patent; SCHERING CORPORATION; WO2009/20580; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem