Adding a certain compound to certain chemical reactions, such as: 14248-50-1, 4-Bromopyridine 1-oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14248-50-1, blongs to pyridine-derivatives compound. COA of Formula: C5H4BrNO
Synthesis of Compound 26.5 [0251] To a mixture of 26.4 (2.6 g, 7.5 mmol, 1.0 eq) and 4-bromopyridine 1-oxide (1.3 g, 7.5 mmol, 1.0 eq) in DCM (150 mL), PyBrop (4.6 g, 9.5 mmol, 1.3 eq) and DIPEA (3.9 g, 30.1 mmol, 4.0 eq) were added. The mixture was stirred at room temperature for 12 h. The mixture was washed with water (50 mL x 2). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column (PE / EA = 2 / 1) to give 26.5 (1.6 g, yield: 42%) as a yellow oil. 1H NMR (400 MHz, CDC13) delta: 7.89-7.86 (m, 2H), 7.56-7.54 (m, 1H), 6.98 (d, J = 8.8 Hz, 1H), 6.69 (dd, J = 1.6, 5.6 Hz, 1H), 6.56 (d, J = 1.6 Hz, 1H), 4.75-4.72 (m, 1H), 4.11 (t, J = 6.0 Hz, 2H), 3.46 (s, 2H), 3.30- 3.25 (m, 2H), 2.60-2.53 (m, 4H), 1.19-1.84 (m, 2H), 1.70-1.60 (m, 8H), 1.51-1.41 (m, 2H); ESI-MS (M+H)+: 503.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14248-50-1, its application will become more common.
Reference:
Patent; BIOGEN IDEC MA INC.; JENKINS, Tracy; VESSELS, Jeffery; WO2014/143672; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem