Synthetic Route of 869108-35-0 , The common heterocyclic compound, 869108-35-0, name is Methyl 3-fluoropyridine-2-carboxylate, molecular formula is C7H6FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Compound 66:; To a solution of LDA (1.8M in THF/heptane ; 72.0 ml_ ; 129 mmol ; 2.1 eq.) in THF (60 ml_) at -78C was added ierf-butylacetate (20.0 ml_ ; 148 mmol ; 2.4 eq.). The deep red solution was stirred at -78C for 45 minutes and maintained at that temperature during the slow addition of a solution of compound 63 (9.5 g ; 62 mmol ; 1 eq.) in THF (60 mL). The reaction mixture was then stirred for an additional 2 hours and quenched at -78C by addition of MTBE (150 mL) and water/acetic acid (1 :1 ; 150 mL). After warming up to room temperature, the layers were separated and the aqueous phase was extracted with MTBE (2 chi 100 mL). The combined organic phases were washed with water (300 mL) and brine (300 mL), dried over Na2S04, filtered and evaporated to dryness to afford compound 66 as an yellow oil (16.2 g ; contaminated with 8.5% W of acetic acid ; yield = 00%).
The synthetic route of 869108-35-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CRITICAL OUTCOME TECHNOLOGIES INC.; DANTER, Wayne; THRELFALL, Clinton; GUIZZETTI, Sylvain; MARIN, Julien; WO2011/120153; (2011); A1;,
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