Some tips on 152126-31-3

With the rapid development of chemical substances, we look forward to future research findings about 152126-31-3.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 152126-31-3, name is 3-Fluoropicolinic acid, molecular formula is C6H4FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H4FNO2

General method for Examples 43-48Carboxylic acid (0.266 mmol), DMF (0.5 ml.) and DIPEA (0.084 ml.) were added to a Greenhouse Plus tube. HATU (101 mg) in DMF (1 ml.) was added and the reaction was stirred for 1 h. Methyl 5-(4-aminophenyl)-3-[[(frans-4-methylcyclohexyl)carbonyl](1- methylethyl)amino]-2-thiophenecarboxylate (100 mg, a synthesis of which is described as Intermediate 9) in DMF (1 ml.) was then added and the reaction was stirred at room temperature for 24 h. The solvent was evaporated in vacuo using a Genevac vacuum centrifuge. To the residue was added THF (1 ml_), MeOH (1 ml.) and 2M lithium hydroxide solution (1 ml_). The reaction was stirred for 24 h and was then neutralised with 2N HCI (1 ml_). The mixture was partitioned between EtOAc and water and the organic phases were separated and dried using a hydrophobic frit. The organic phases were evaporated in vacuo using a Genevac vacuum centrifuge and the crude material was purified by MDAP HPLC to give the title compound-Example 435-(4-{[(3-Fluoro-2-pyridinyl)carbonyl]amino}phenyl)-3-[[(frans-4- methylcyclohexyl)carbonyl](1 -methylethyl)amino]-2-thiophenecarboxylic acidMS calcd for (C28H30FN3O4S + H)+: 524MS found (electrospray): (M+H)+ = 5241H NMR (de-DMSO): delta 10.81 (1 H, s), 8.59 (1 H, s), 8.00-7.68 (6H, m), 7.43 (1 H, s), 4.73 (1 H, quintet), 2.01 (1 H, t), 1.70-1.39 (5H, m), 1.31-1.10 (5H, m), 0.90 (3H, d), 0.73 (3H, d), 0.71-0.48 (2H, m), 1 exchangeable proton not seen.

With the rapid development of chemical substances, we look forward to future research findings about 152126-31-3.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/59042; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem