Related Products of 174669-74-0 ,Some common heterocyclic compound, 174669-74-0, molecular formula is C5H4FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Fluoro-3-methoxypyridine (3): 2-Fluoropyridin-3-ol (10 mmol),methyl iodide (20 mmol) and potassium carbonate (20 mmol) in acetone (100 ml) was refluxed overnight. The inorganic salt wasfiltered and the solvent was evaporated. The residue was purified oncolumn (eluent: EtOAc:hexane = 1:5) to afford a colorless liquid [19](95%). 1H NMR (CDCl3): d 7.74-7.75 (m, 1H, C6-H), 7.26-7.31 (m, 1H,C4-H), 7.11-7.15 (m, 1H, C5-H), 3.91 (s, 3H, OMe). 19F NMR (CDCl3): d90.15 (s). ESI-MS: 128 (M+1)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,174669-74-0, its application will become more common.
Reference:
Article; Ma, Yongmin; Hider, Robert C.; Journal of Fluorine Chemistry; vol. 173; (2015); p. 29 – 34;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem